Phenotypes Associated with This Genotype

Genotype
MGI:3770811

• Allelic Composition: Kit^tm1Alf/Kit⁺
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

white spotting ( J:36230 )

• melanoblasts fail to colonize the distal parts of the limb buds and the tail tip resulting in white feet and a white tail tip

non-pigmented tail tip ( J:36230 )

• white tail tip

reproductive system

abnormal oocyte morphology ( J:67923 )

♀ • oocyte growth is altered

abnormal male germ cell morphology ( J:103157 )

♂ • males exhibit a higher number of spermatozoa without acrosomal contents

oligozoospermia ( J:103157 )

♂ • reduction in epididymal sperm counts

asthenozoospermia ( J:103157 )

♂ • decrease in sperm motility

abnormal female reproductive system morphology ( J:67923 )

♀

abnormal ovarian follicle number ( J:67923 )

♀ • ovaries contain increased numbers of type 5a follicles and fewer numbers of type 5b (preantral follicles) follicles

decreased primordial ovarian follicle number ( J:67923 )

♀ • primordial follicle numbers decrease with increasing age

abnormal ovarian folliculogenesis ( J:67923 )

♀ • antrum formation in preantral follicles is disrupted at P20, as fewer preantral follicles with 3 or 4 layers of granulosa cells develop an antral cavity

abnormal male reproductive system morphology ( J:103157 )

♂

decreased testis weight ( J:103157 )

♂ • testes weights are 50% lower than in wild-type

♂ • however, no difference in seminal vesicle weight

decreased epididymis weight ( J:103157 )

♂ • epididymides weights are 25% lower than in wild-type before 30 days of age; at 30 days of age when no spermatozoa are present, weights do not differ

reduced male fertility ( J:103157 )

♂ • in vivo and in vitro fertility is greatly reduced in males

♂ • female fertility is normal

limbs/digits/tail

non-pigmented tail tip ( J:36230 )

• white tail tip

endocrine/exocrine glands

abnormal ovarian follicle number ( J:67923 )

♀ • ovaries contain increased numbers of type 5a follicles and fewer numbers of type 5b (preantral follicles) follicles

decreased primordial ovarian follicle number ( J:67923 )

♀ • primordial follicle numbers decrease with increasing age

abnormal ovarian folliculogenesis ( J:67923 )

♀ • antrum formation in preantral follicles is disrupted at P20, as fewer preantral follicles with 3 or 4 layers of granulosa cells develop an antral cavity

decreased testis weight ( J:103157 )

♂ • testes weights are 50% lower than in wild-type

♂ • however, no difference in seminal vesicle weight

embryo

abnormal melanoblast migration ( J:36230 )

• melanoblasts fail to colonize the distal parts of the limb buds and the tail tip

integument

white spotting ( J:36230 )

• melanoblasts fail to colonize the distal parts of the limb buds and the tail tip resulting in white feet and a white tail tip

non-pigmented tail tip ( J:36230 )

• white tail tip

cellular

abnormal oocyte morphology ( J:67923 )

♀ • oocyte growth is altered

abnormal male germ cell morphology ( J:103157 )

♂ • males exhibit a higher number of spermatozoa without acrosomal contents

oligozoospermia ( J:103157 )

♂ • reduction in epididymal sperm counts

abnormal melanoblast migration ( J:36230 )

• melanoblasts fail to colonize the distal parts of the limb buds and the tail tip

asthenozoospermia ( J:103157 )

♂ • decrease in sperm motility