Phenotypes Associated with This Genotype

Genotype
MGI:3770780

• Allelic Composition: Kit^tm1Alf/Kit^tm1Alf
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:103157 , J:36230 )

• newborns rapidly die after birth (J:36230)

hematopoietic system

anemia ( J:103157 )

• severe megaloblastic anemia

macrocytic anemia ( J:36230 )

• severe macrocytic and hyperchromic anemia

pigmentation

abnormal melanocyte morphology ( J:36230 )

• melanocytes are absent form the skin of newborns

reproductive system

abnormal female germ cell morphology ( J:36230 )

♀ • no beta-gal positive cells are found in the ovaries of homozygote newborns, indicating that migration, proliferation, and/or survival of germ cells is impaired

abnormal primordial germ cell migration ( J:36230 )

• migration of primordial germ cells (PGC) cells at E9.5 is impaired, with PGCs found in the ventral half of the gut and sometimes grouped in clumps in ectopic sites such as inside of the vitelline artery, instead of being found in the gut wall

embryo

abnormal melanoblast migration ( J:36230 )

• from E11 onwards, melanoblasts are absent from the surface ectoderm of embryos, indicating that migration/survival of melanoblasts is impaired from E10.5 onwards

integument

pallor ( J:36230 )

• newborns are pale

cellular

abnormal female germ cell morphology ( J:36230 )

♀ • no beta-gal positive cells are found in the ovaries of homozygote newborns, indicating that migration, proliferation, and/or survival of germ cells is impaired

abnormal melanoblast migration ( J:36230 )

• from E11 onwards, melanoblasts are absent from the surface ectoderm of embryos, indicating that migration/survival of melanoblasts is impaired from E10.5 onwards

abnormal primordial germ cell migration ( J:36230 )

• migration of primordial germ cells (PGC) cells at E9.5 is impaired, with PGCs found in the ventral half of the gut and sometimes grouped in clumps in ectopic sites such as inside of the vitelline artery, instead of being found in the gut wall