Phenotypes Associated with This Genotype

Genotype
MGI:3770685

• Allelic Composition: Ngfr^tm1Jae/Ngfr^tm1Jae
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased neuron apoptosis ( J:123022 )

• at E12 and E14, neuron apoptosis is reduced 72% and 70%, respectively, compared to in wild-type mice

• nearly all neurons cultured with NT4 survive unlike wild-type neurons

abnormal axon guidance ( J:145459 )

• when given the choice between strips that contain Eph47-Fc or Fc, retinal axons fail to avoid EPHA7-Fc stripes or exhibit a preference for the Fc stripes unlike wild-type axons

• however, avoidance of stripes with EPHA5-Fc is normal

abnormal superior colliculus morphology ( J:145459 )

• however, total area of the superior colliculus is normal

• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice

• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice

abnormal sensory neuron innervation pattern ( J:43749 )

• absence of sensory innervation to pineal and sweat glands

abnormal cholinergic neuron morphology ( J:62379 )

• increased size of cholinergic forebrain neurons

abnormal retina ganglion cell morphology ( J:145459 )

• 50% of mice exhibit ectopic branches and arbors along the anterior posterior length of the nasal RGC axons in the superior colliculus unlike in wild-type mice

• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice

• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice

abnormal trigeminal ganglion morphology ( J:157604 )

• ophthalmic branch of the trigeminal ganglion is severely truncated at E12.5

behavior/neurological

abnormal spatial learning ( J:62379 )

• spatial learning is improved compared to in wild-type mice without deterioration with age

vision/eye

abnormal retina ganglion cell morphology ( J:145459 )

• 50% of mice exhibit ectopic branches and arbors along the anterior posterior length of the nasal RGC axons in the superior colliculus unlike in wild-type mice

• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice

• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice

abnormal eye physiology ( J:157549 )

• mice subjected to intraocular injection of the pro form of nerve growth factor are protected from induced retinal ganglion cell death

homeostasis/metabolism

abnormal tumor necrosis factor level ( J:157549 )

• the pro form of nerve growth factor fails to induce TNF expression in retinas

immune system

abnormal tumor necrosis factor level ( J:157549 )

• the pro form of nerve growth factor fails to induce TNF expression in retinas

cellular

decreased neuron apoptosis ( J:123022 )

• at E12 and E14, neuron apoptosis is reduced 72% and 70%, respectively, compared to in wild-type mice

• nearly all neurons cultured with NT4 survive unlike wild-type neurons

abnormal axon guidance ( J:145459 )

• when given the choice between strips that contain Eph47-Fc or Fc, retinal axons fail to avoid EPHA7-Fc stripes or exhibit a preference for the Fc stripes unlike wild-type axons

• however, avoidance of stripes with EPHA5-Fc is normal