Analysis Tools
mortality/aging
 N |
• males survive >18 months
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• males are born at ~40% of expected frequency (84/211 total males)
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growth/size/body
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• initially males are ~60% size of wild-type littermates
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• by adulthood, males attain ~80% the size of wild-type littermates
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nervous system
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N |
• the optic chiasm, corpus callosum, and spinal commissural projection in mutants show normal axonal pathfinding and crossing projections, in contrast to the pyramidal decussation
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• in P3-P5 animals, very few corticospinal axons grow to the contralateral dorsal columns at the pyramidal decussation; many axons instead turn ventrally at midline and enter the contralateral pyramid
• in one animal, aberrant axons turn rostrally in contralateral pyramid and project back towards midbrain; in other animals, axons can't be traced beyond decussation
• no axons are apparent caudal to the decussation, either ventrally or dorsally
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• in adult males examined, corticospinal axons project normally to the medulla, but at the level of the decussation, a substantial portion of axons fail to cross the midline and instead pass ipsilaterally into the dorsal columns
• no axon labeling is detected more caudally than the cervical spinal cord in male mutants
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behavior/neurological
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• dragging of hindlimbs is observed in some mice >12 months of age
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reproductive system
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N |
• although males are sterile, testis contain germ cells
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• some individuals are able to breed but most are effectively sterile
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vision/eye
enophthalmos
(
J:45013
)
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• adult mutants have sunken eyes
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• adult mutants have lacrimous eyes
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pigmentation
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• Background Sensitivity: with age, mice on congenic 129/Sv agouti background develop patches of black fur on their backs
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integument
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• Background Sensitivity: with age, mice on congenic 129/Sv agouti background develop patches of black fur on their backs
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long toenails
(
J:45013
)
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• Background Sensitivity: mice have abnormally long hind-paw toenails (4-5 mm) on congenic 129/Sv background
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cellular
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• in P3-P5 animals, very few corticospinal axons grow to the contralateral dorsal columns at the pyramidal decussation; many axons instead turn ventrally at midline and enter the contralateral pyramid
• in one animal, aberrant axons turn rostrally in contralateral pyramid and project back towards midbrain; in other animals, axons can't be traced beyond decussation
• no axons are apparent caudal to the decussation, either ventrally or dorsally
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limbs/digits/tail
long toenails
(
J:45013
)
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• Background Sensitivity: mice have abnormally long hind-paw toenails (4-5 mm) on congenic 129/Sv background
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