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Phenotypes Associated with This Genotype
Genotype
MGI:3770650
Allelic
Composition
L1camtm1Sor/Y
Genetic
Background
either: 129S7/SvEvBrd-L1camtm1Sor or (129S7/SvEvBrd * C57BL/6J)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
L1camtm1Sor mutation (2 available); any L1cam mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• males survive >18 months
• males are born at ~40% of expected frequency (84/211 total males)

growth/size/body
• initially males are ~60% size of wild-type littermates
• by adulthood, males attain ~80% the size of wild-type littermates

nervous system
N
• the optic chiasm, corpus callosum, and spinal commissural projection in mutants show normal axonal pathfinding and crossing projections, in contrast to the pyramidal decussation
• in P3-P5 animals, very few corticospinal axons grow to the contralateral dorsal columns at the pyramidal decussation; many axons instead turn ventrally at midline and enter the contralateral pyramid
• in one animal, aberrant axons turn rostrally in contralateral pyramid and project back towards midbrain; in other animals, axons can't be traced beyond decussation
• no axons are apparent caudal to the decussation, either ventrally or dorsally
• in adult males examined, corticospinal axons project normally to the medulla, but at the level of the decussation, a substantial portion of axons fail to cross the midline and instead pass ipsilaterally into the dorsal columns
• no axon labeling is detected more caudally than the cervical spinal cord in male mutants

behavior/neurological
• dragging of hindlimbs is observed in some mice >12 months of age

reproductive system
N
• although males are sterile, testis contain germ cells
• some individuals are able to breed but most are effectively sterile

vision/eye
• adult mutants have sunken eyes
• adult mutants have lacrimous eyes

pigmentation
• Background Sensitivity: with age, mice on congenic 129/Sv agouti background develop patches of black fur on their backs

integument
• Background Sensitivity: with age, mice on congenic 129/Sv agouti background develop patches of black fur on their backs
• Background Sensitivity: mice have abnormally long hind-paw toenails (4-5 mm) on congenic 129/Sv background

cellular
• in P3-P5 animals, very few corticospinal axons grow to the contralateral dorsal columns at the pyramidal decussation; many axons instead turn ventrally at midline and enter the contralateral pyramid
• in one animal, aberrant axons turn rostrally in contralateral pyramid and project back towards midbrain; in other animals, axons can't be traced beyond decussation
• no axons are apparent caudal to the decussation, either ventrally or dorsally


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory