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Phenotypes Associated with This Genotype
Genotype
MGI:3770518
Allelic
Composition
Krastm2Tyj/Kras+
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm2Tyj mutation (1 available); any Kras mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: mean age at death is ~350 days on pure 129/Sv background compared to 300 days on mixed background (J:68981)
• average lifespan is 373 days (J:68981)
• Background Sensitivity: mean age at death is ~350 days on pure 129/Sv background compared to 300 days on mixed background (J:68981)
• average lifespan is 373 days (J:68981)

tumorigenesis
• mice develop adenocarcinomas, adenomas, lymphomas, mesotheliomas, angiosarcomas, fibrosarcomas, squamous carcinomas, rectal mucinous adenocarcinomas, melanomas, and papillomas (J:129627)
• mice develop adenocarcinomas, adenomas, lymphomas, mesotheliomas, angiosarcomas, fibrosarcomas, squamous carcinomas, rectal mucinous adenocarcinomas, melanomas, and papillomas (J:129627)
• Background Sensitivity: ~10% of animals develop thymic lymphoma; incidence is lower than on pure 129/Sv background (J:68981)
• Background Sensitivity: ~10% of animals develop thymic lymphoma; incidence is lower than on pure 129/Sv background (J:68981)
• develop lung adenocarcinomas by 6-8 months of age (J:136369)
• treatment of mice with PX-866, a PI3K inhibitor, decreases lung lesion volume and multiplicity (J:136369)
• develop lung adenocarcinomas by 6-8 months of age (J:136369)
• treatment of mice with PX-866, a PI3K inhibitor, decreases lung lesion volume and multiplicity (J:136369)
• 4 of 48 mice develop mesothelioma with no occurrence of peritoneal mesothelioma (J:129627)
• 4 of 48 mice develop mesothelioma with no occurrence of peritoneal mesothelioma (J:129627)
• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background (J:68981)
• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background (J:68981)

integument
• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background (J:68981)
• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background (J:68981)

respiratory system
• a subset of mutant terminal bronchi contain 4 to 7 bronchioalveolar stem cells (BASCs) compared to 3 of fewer in wild-type bronchi, indicating expansion of BASCs (J:136369)
• a subset of mutant terminal bronchi contain 4 to 7 bronchioalveolar stem cells (BASCs) compared to 3 of fewer in wild-type bronchi, indicating expansion of BASCs (J:136369)

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:68981 , J:136369


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory