Mouse Genome Informatics
ht
    Krastm2Tyj/Kras+
involves: 129S2/SvPas
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• Background Sensitivity: mean age at death is ~350 days on pure 129/Sv background compared to 300 days on mixed background (J:68981)
• average lifespan is 373 days (J:68981)

tumorigenesis
• mice develop adenocarcinomas, adenomas, lymphomas, mesotheliomas, angiosarcomas, fibrosarcomas, squamous carcinomas, rectal mucinous adenocarcinomas, melanomas, and papillomas
• Background Sensitivity: ~10% of animals develop thymic lymphoma; incidence is lower than on pure 129/Sv background
• develop lung adenocarcinomas by 6-8 months of age
• treatment of mice with PX-866, a PI3K inhibitor, decreases lung lesion volume and multiplicity
• 4 of 48 mice develop mesothelioma with no occurrence of peritoneal mesothelioma
• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background

integument
• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background

respiratory system
• a subset of mutant terminal bronchi contain 4 to 7 bronchioalveolar stem cells (BASCs) compared to 3 of fewer in wild-type bronchi, indicating expansion of BASCs

Mouse Models of Human Disease
OMIM IDRef(s)
Lung Cancer 211980 J:68981 , J:136369