Mouse Genome Informatics
ht
    Krastm3Tyj/Kras+
involves: 129S2/SvPas
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• Background Sensitivity: mean age at death is ~250 days on pure 129/Sv background compared to 200 days on mixed background

tumorigenesis
• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background
• Background Sensitivity: ~30% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background
• 100% of mice examined at 3-4 months of age have developed lung tumors

integument
• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background

Mouse Models of Human Disease
OMIM IDRef(s)
Lung Cancer 211980 J:68981