About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3770517
Allelic
Composition
Krastm3Tyj/Kras+
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm3Tyj mutation (2 available); any Kras mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• 100% of mice examined at 3-4 months of age have developed lung tumors

endocrine/exocrine glands
• Background Sensitivity: ~30% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background

mortality/aging
• Background Sensitivity: mean age at death is ~250 days on pure 129/Sv background compared to 200 days on mixed background

neoplasm
• Background Sensitivity: ~30% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background
• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background
• 100% of mice examined at 3-4 months of age have developed lung tumors

integument
• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:68981


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory