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Phenotypes Associated with This Genotype
Genotype
MGI:3770515
Allelic
Composition
Krastm2Tyj/Kras+
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm2Tyj mutation (1 available); any Kras mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: mean age at death is ~300 days (J:68981)
• Background Sensitivity: mean age at death is ~300 days (J:68981)

tumorigenesis
• all animals at time of death/sacrifice have extensive tumor burden (J:68981)
• all animals at time of death/sacrifice have extensive tumor burden (J:68981)
• Background Sensitivity: animals are prone to skin papillomas (seen in ~25% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma (J:68981)
• Background Sensitivity: animals are prone to skin papillomas (seen in ~25% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma (J:68981)
• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~20% of animals) (J:68981)
• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~20% of animals) (J:68981)
• 100% of animals show multifocal tumors at time of death/sacrifice (J:68981)
• tumors are detectable at 1 week of age as small pleural nodules; multiplicity and size of tumors increases with age, and ultimately result in respiratory distress and death (J:68981)
• tumors range from mild hyperplasia/dysplasia to overt carcinoma; small lesions consist of hyperplastic alveolar epithelium (J:68981)
• in older mice, infrequent metastases to thoracic lymph nodes, the kidney and other visceral organs (J:68981)
• 100% of animals show multifocal tumors at time of death/sacrifice (J:68981)
• tumors are detectable at 1 week of age as small pleural nodules; multiplicity and size of tumors increases with age, and ultimately result in respiratory distress and death (J:68981)
• tumors range from mild hyperplasia/dysplasia to overt carcinoma; small lesions consist of hyperplastic alveolar epithelium (J:68981)
• in older mice, infrequent metastases to thoracic lymph nodes, the kidney and other visceral organs (J:68981)
• as lesions enlarge, they form small alveolar adenomas; some show areas of glandular differentiation (J:68981)
• as lesions enlarge, they form small alveolar adenomas; some show areas of glandular differentiation (J:68981)
• 5-10% of tumors have features of well-differentiated human papillary adenocarcinoma (J:68981)
• 5-10% of tumors have features of well-differentiated human papillary adenocarcinoma (J:68981)

digestive/alimentary system
• mutants have multiple aberrant crypt foci (ACF) of the colon (J:68981)
• mutants have multiple aberrant crypt foci (ACF) of the colon (J:68981)

endocrine/exocrine glands
• mutants have multiple aberrant crypt foci (ACF) of the colon (J:68981)
• mutants have multiple aberrant crypt foci (ACF) of the colon (J:68981)

integument
• Background Sensitivity: animals are prone to skin papillomas (seen in ~25% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma (J:68981)
• Background Sensitivity: animals are prone to skin papillomas (seen in ~25% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma (J:68981)

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:68981


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory