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Phenotypes Associated with This Genotype
Genotype
MGI:3770515
Allelic
Composition
Krastm2Tyj/Kras+
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm2Tyj mutation (1 available); any Kras mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• 100% of animals show multifocal tumors at time of death/sacrifice
• tumors are detectable at 1 week of age as small pleural nodules; multiplicity and size of tumors increases with age, and ultimately result in respiratory distress and death
• tumors range from mild hyperplasia/dysplasia to overt carcinoma; small lesions consist of hyperplastic alveolar epithelium
• in older mice, infrequent metastases to thoracic lymph nodes, the kidney and other visceral organs
• as lesions enlarge, they form small alveolar adenomas; some show areas of glandular differentiation
• 5-10% of tumors have features of well-differentiated human papillary adenocarcinoma

mortality/aging
• Background Sensitivity: mean age at death is ~300 days

neoplasm
• all animals at time of death/sacrifice have extensive tumor burden
• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~20% of animals)
• Background Sensitivity: animals are prone to skin papillomas (seen in ~25% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma
• 100% of animals show multifocal tumors at time of death/sacrifice
• tumors are detectable at 1 week of age as small pleural nodules; multiplicity and size of tumors increases with age, and ultimately result in respiratory distress and death
• tumors range from mild hyperplasia/dysplasia to overt carcinoma; small lesions consist of hyperplastic alveolar epithelium
• in older mice, infrequent metastases to thoracic lymph nodes, the kidney and other visceral organs
• as lesions enlarge, they form small alveolar adenomas; some show areas of glandular differentiation
• 5-10% of tumors have features of well-differentiated human papillary adenocarcinoma

digestive/alimentary system
• mutants have multiple aberrant crypt foci (ACF) of the colon

endocrine/exocrine glands
• mutants have multiple aberrant crypt foci (ACF) of the colon
• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~20% of animals)

integument
• Background Sensitivity: animals are prone to skin papillomas (seen in ~25% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:68981


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory