Phenotypes Associated with This Genotype

Genotype
MGI:3770515

• Allelic Composition: Kras^tm2Tyj/Kras⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:68981 )

• Background Sensitivity: mean age at death is ~300 days

neoplasm

increased tumor incidence ( J:68981 )

• all animals at time of death/sacrifice have extensive tumor burden

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~20% of animals)

increased skin papilloma incidence ( J:68981 )

• Background Sensitivity: animals are prone to skin papillomas (seen in ~25% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma

increased lung tumor incidence ( J:68981 )

• 100% of animals show multifocal tumors at time of death/sacrifice

• tumors are detectable at 1 week of age as small pleural nodules; multiplicity and size of tumors increases with age, and ultimately result in respiratory distress and death

• tumors range from mild hyperplasia/dysplasia to overt carcinoma; small lesions consist of hyperplastic alveolar epithelium

• in older mice, infrequent metastases to thoracic lymph nodes, the kidney and other visceral organs

increased lung adenoma incidence ( J:68981 )

• as lesions enlarge, they form small alveolar adenomas; some show areas of glandular differentiation

increased lung adenocarcinoma incidence ( J:68981 )

• 5-10% of tumors have features of well-differentiated human papillary adenocarcinoma

digestive/alimentary system

abnormal large intestine crypts of Lieberkuhn morphology ( J:68981 )

• mutants have multiple aberrant crypt foci (ACF) of the colon

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:68981 )

• mutants have multiple aberrant crypt foci (ACF) of the colon

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~20% of animals)

integument

increased skin papilloma incidence ( J:68981 )

• Background Sensitivity: animals are prone to skin papillomas (seen in ~25% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma

respiratory system

increased lung tumor incidence ( J:68981 )

• tumors range from mild hyperplasia/dysplasia to overt carcinoma; small lesions consist of hyperplastic alveolar epithelium

• 100% of animals show multifocal tumors at time of death/sacrifice

• tumors are detectable at 1 week of age as small pleural nodules; multiplicity and size of tumors increases with age, and ultimately result in respiratory distress and death

• in older mice, infrequent metastases to thoracic lymph nodes, the kidney and other visceral organs

increased lung adenoma incidence ( J:68981 )

• as lesions enlarge, they form small alveolar adenomas; some show areas of glandular differentiation

increased lung adenocarcinoma incidence ( J:68981 )

• 5-10% of tumors have features of well-differentiated human papillary adenocarcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:68981