Phenotypes for Tg(IGFBP1)2Miel MGI:3770280 MGI Mouse

prenatal lethality ( J:78353 )

• fetal death rate in litters of transgenic dams is 12%, compared to no lethality in litters from wild-type dams

embryonic growth retardation ( J:78353 )

• at E11.5, embryonic growth restriction is observed in transgenic dams

• at E14.5 and 17.5 fetal growth is similar in transgenic and wild-type dams

• at E11.5, fetuses exhibit a ~10% reduction in weight compared to wild-type fetuses; difference is less at E14.5 and by E17.5, mutants and wild-type have very similar growth characteristics

abnormal maternal decidual layer morphology ( J:78353 )

• decidual component of placentas in wild-type dams is greater than that of transgenic dams

abnormal placenta junctional zone morphology ( J:78353 )

• junctional zone is larger in placentae from wild-type females compared to transgenic mice

abnormal spongiotrophoblast layer morphology ( J:78353 )

• ratio of spongiotrophoblasts to glycogen cells is higher in transgenic females

increased placental labyrinth size ( J:78353 )

• labyrinthine zone is grossly enlarged in transgenic females, occupying 80% of cross-sectional area of placenta in transgenic females, compared to ~50% of area in wild-type females

increased placenta weight ( J:78353 )

• transgenic dams have higher mean placental weights throughout gestation

abnormal decidualization ( J:78353 )