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Phenotypes Associated with This Genotype
Genotype
MGI:3770250
Allelic
Composition		 Stat3tm2Aki/Stat3tm2Aki
Tg(Lck-cre)1Jtak/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm2Aki mutation (1 available); any Stat3 mutation (72 available)
Tg(Lck-cre)1Jtak mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell apoptosis ( J:50443 )
• T cells fail to exhibit an anti-apoptotic effect in response to IL-6 unlike in wild-type mice
decreased T cell proliferation ( J:50443 )
• proliferate in response to IL-6 plus anti-CD3, IL-2 or IL-6 plus ConA stimulation in decreased or absent unlike wild-type mice
• however, proliferation in response to IL-7 is normal

hematopoietic system
increased T cell apoptosis ( J:50443 )
• T cells fail to exhibit an anti-apoptotic effect in response to IL-6 unlike in wild-type mice
decreased T cell proliferation ( J:50443 )
• proliferate in response to IL-6 plus anti-CD3, IL-2 or IL-6 plus ConA stimulation in decreased or absent unlike wild-type mice
• however, proliferation in response to IL-7 is normal

cellular
increased T cell apoptosis ( J:50443 )
• T cells fail to exhibit an anti-apoptotic effect in response to IL-6 unlike in wild-type mice
decreased T cell proliferation ( J:50443 )
• proliferate in response to IL-6 plus anti-CD3, IL-2 or IL-6 plus ConA stimulation in decreased or absent unlike wild-type mice
• however, proliferation in response to IL-7 is normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory