Phenotypes Associated with This Genotype

Genotype
MGI:3770153

• Allelic Composition: Pbx1^tm1.1Febe/Pbx1⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased adrenal gland zona fasciculata size ( J:129552 )

• mice exhibit a reduction in the number of cells in the zona fasciculate (63.3+/-3.3% compared to 89.3+/-8.3% in wild-type mice)

small adrenal glands ( J:129552 )

• 4.4+/-0.4 mg compared to 7.5+/-0.3 mg in wild-type mice

• adrenal glands are smaller due to decreased proliferation

• adrenal glands exhibit decreased compensatory adrenal growth compared to in wild-type mice when one adrenal is removed

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:129552 )

• mice exhibit a blunted steroid response after stimulation with ACTH

• however, corticosterone response following restrained stress experiments is normal