Phenotypes Associated with This Genotype

Genotype
MGI:3769901

• Allelic Composition: Tcrb^tm1Mom/Tcrb^tm1Mom; Tcrd^tm1Mom/Tcrd^tm1Mom
• Genetic Background: involves: 129 * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

colitis ( J:15221 )

• very mild colitis occurs in some aged mice

thymus hypoplasia ( J:3206 )

• about a 95% reduction in number of total thymocytes

decreased double-positive T cell number ( J:3206 )

• double positive cells are not present

arrested T cell differentiation ( J:3206 )

• most T cells in the thymus do no progress to the double negative stage

absent CD4-positive, alpha-beta T cells ( J:3206 )

• cells are absent in the thymus

absent CD8-positive, alpha-beta T cells ( J:3206 )

• cells are absent in the thymus

digestive/alimentary system

colitis ( J:15221 )

• very mild colitis occurs in some aged mice

hematopoietic system

thymus hypoplasia ( J:3206 )

• about a 95% reduction in number of total thymocytes

decreased double-positive T cell number ( J:3206 )

• double positive cells are not present

arrested T cell differentiation ( J:3206 )

• most T cells in the thymus do no progress to the double negative stage

absent CD4-positive, alpha-beta T cells ( J:3206 )

• cells are absent in the thymus

absent CD8-positive, alpha-beta T cells ( J:3206 )

• cells are absent in the thymus

endocrine/exocrine glands

thymus hypoplasia ( J:3206 )

• about a 95% reduction in number of total thymocytes