Phenotypes Associated with This Genotype

Genotype
MGI:3769682

• Allelic Composition: Tg(RSV-BDKRB2)8905Chao/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased systemic arterial blood pressure ( J:128651 )

• 84.2+/-0.6 mm Hg compared to 96.9+/-0.4 mm Hg in wild-type mice

• treatment with a vasodepressor results in a more dramatic drop in blood pressure than in wild-type mice

• however, injection of Hoe 104, a bradykinin beta 2 receptor antagonist, restores normal blood pressure

muscle

impaired smooth muscle contractility ( J:128651 )

• uterine smooth muscle contraction stimulated by 0.5 umol/l Bradykinin is decreased three-fold compared to in wild-type mice

• however, there is no difference in KCL-stimulated contractions