Phenotypes Associated with This Genotype

Genotype
MGI:3769496

• Allelic Composition: Sphk2^tm1Npa/Sphk2^tm1Npa
• Genetic Background: BALB/c-Sphk2^tm1Npa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell number ( J:129314 )

• when treated with 1mg/kg FTY720, mice fail to exhibit reduction in peripheral lymphocytes compared to wild-type mice

abnormal B cell physiology ( J:129314 )

• unlike in wild-type mice, lymphocyte migration in FTY720-treated mice continue to migrate in response to S1P (shingosine-1-phosphate)

hematopoietic system

increased B cell number ( J:129314 )

• when treated with 1mg/kg FTY720, mice fail to exhibit reduction in peripheral lymphocytes compared to wild-type mice

abnormal B cell physiology ( J:129314 )

• unlike in wild-type mice, lymphocyte migration in FTY720-treated mice continue to migrate in response to S1P (shingosine-1-phosphate)