Phenotypes Associated with This Genotype

Genotype
MGI:3769383

• Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺; Kat8^tm1Thl/Kat8⁺
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cellular sensitivity to ionizing radiation induced cell death ( J:128936 )

• following treatment with tamoxifen, cell survival of mouse embryonic fibroblasts following treatment with ionizing radiation is slightly decreased compared to in wild-type cells

decreased fibroblast proliferation ( J:128936 )

• following treatment with tamoxifen, mouse embryonic fibroblasts exhibit a modest decrease in proliferation compared to wild-type

abnormal DNA repair ( J:128936 )

• following treatment with tamoxifen, the number of chromosome abnormalities in mouse embryonic fibroblasts is increased compared to in wild-type cells

homeostasis/metabolism

increased cellular sensitivity to ionizing radiation induced cell death ( J:128936 )

• following treatment with tamoxifen, cell survival of mouse embryonic fibroblasts following treatment with ionizing radiation is slightly decreased compared to in wild-type cells

abnormal DNA repair ( J:128936 )

• following treatment with tamoxifen, the number of chromosome abnormalities in mouse embryonic fibroblasts is increased compared to in wild-type cells