About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3769375
Allelic
Composition		 Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2Rob
Smad5tm1Huy/Smad5tm1Zuk
Smad9tm1Jfm/Smad9tm1Jfm
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (24 available)
Smad1tm2Rob mutation (2 available); any Smad1 mutation (34 available)
Smad5tm1Huy mutation (0 available); any Smad5 mutation (26 available)
Smad5tm1Zuk mutation (1 available); any Smad5 mutation (26 available)
Smad9tm1Jfm mutation (0 available); any Smad9 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased ovary tumor incidence ( J:128934 )
• after 3 months of age, 100% of female mice have unilateral or bilateral ovarian tumors
increased ovarian carcinoma incidence ( J:128934 )
• over 70% of female mice have metastic ovarian cancer by 1 year of age

mortality/aging
early reproductive senescence ( J:128934 )
• female mice become infertile after 3 to 4 months of breeding

reproductive system
increased ovary tumor incidence ( J:128934 )
• after 3 months of age, 100% of female mice have unilateral or bilateral ovarian tumors
increased ovarian carcinoma incidence ( J:128934 )
• over 70% of female mice have metastic ovarian cancer by 1 year of age
early reproductive senescence ( J:128934 )
• female mice become infertile after 3 to 4 months of breeding

neoplasm
increased ovary tumor incidence ( J:128934 )
• after 3 months of age, 100% of female mice have unilateral or bilateral ovarian tumors
increased ovarian carcinoma incidence ( J:128934 )
• over 70% of female mice have metastic ovarian cancer by 1 year of age

cardiovascular system
hemoperitoneum ( J:128934 )
• found in 50% of female mice over 9 months in age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory