Phenotypes Associated with This Genotype

Genotype
MGI:3769365

• Allelic Composition: Amhr2^tm3(cre)Bhr/Amhr2⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

early reproductive senescence ( J:128934 )

• female mice become infertile after 3 to 4 months of breeding

reproductive system

increased ovary tumor incidence ( J:128934 )

♀ • after 3 months of age, 100% of female mice have unilateral or bilateral ovarian tumors

increased ovarian carcinoma incidence ( J:128934 )

♀ • over 70% of female mice have metastic ovarian cancer by 1 year of age

increased testis tumor incidence ( J:128934 )

♂ • 100% of male mice by 7 months of age exhibit tumors in the testis

♂ • early stage tumors appear to be sex cord stromal tumors with Sertoli and Leydig cell differentiation

early reproductive senescence ( J:128934 )

• female mice become infertile after 3 to 4 months of breeding

male infertility ( J:128934 )

♂ • slight infertility, with a 16% decrease in litters per month when bred to wild-type females

neoplasm

increased ovary tumor incidence ( J:128934 )

♀ • after 3 months of age, 100% of female mice have unilateral or bilateral ovarian tumors

increased ovarian carcinoma incidence ( J:128934 )

♀ • over 70% of female mice have metastic ovarian cancer by 1 year of age

increased testis tumor incidence ( J:128934 )

♂ • 100% of male mice by 7 months of age exhibit tumors in the testis

♂ • early stage tumors appear to be sex cord stromal tumors with Sertoli and Leydig cell differentiation

cardiovascular system

hemoperitoneum ( J:128934 )

• found in 50% of female mice over 9 months in age

• found in about 60% of male mice by 11 months in age

endocrine/exocrine glands

increased ovary tumor incidence ( J:128934 )

♀ • after 3 months of age, 100% of female mice have unilateral or bilateral ovarian tumors

increased ovarian carcinoma incidence ( J:128934 )

♀ • over 70% of female mice have metastic ovarian cancer by 1 year of age

increased testis tumor incidence ( J:128934 )

♂ • 100% of male mice by 7 months of age exhibit tumors in the testis

♂ • early stage tumors appear to be sex cord stromal tumors with Sertoli and Leydig cell differentiation