Phenotypes Associated with This Genotype

Genotype
MGI:3769356

• Allelic Composition: Jak3^tm1Ljb/Jak3^tm1Ljb; Tg(Lck-Jak3)2Ljb/0
• Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:128694 )

N • unlike null mice without the transgene, thymic cellularity, the ratio of CD4+ to CD8+ cells in the thymus, T cell maturation in the spleen, and the numbers of gamma delta T and NK cells are normal

absent B cells ( J:128694 )

• absence of CD45R+ IgM+ cells in the bone marrow

abnormal T cell physiology ( J:128694 )

• the ability of splenic T cells to secrete IL12 in response to T cell receptor plus CD28 stimulation decreases with age (from 25 to 42 days of age)

abnormal T cell activation ( J:128694 )

• as mice age the proportion of CD4+ T cells that resemble activated or memory T cells increases

• this correlates with the decrease in transgene expression in the periphery as mice age

decreased T cell proliferation ( J:128694 )

• the proliferative response of splenic T cells in response to T cell receptor plus CD28 stimulation is reduced

absent lymph nodes ( J:128694 )

hematopoietic system

absent B cells ( J:128694 )

• absence of CD45R+ IgM+ cells in the bone marrow

abnormal T cell physiology ( J:128694 )

• the ability of splenic T cells to secrete IL12 in response to T cell receptor plus CD28 stimulation decreases with age (from 25 to 42 days of age)

abnormal T cell activation ( J:128694 )

• as mice age the proportion of CD4+ T cells that resemble activated or memory T cells increases

• this correlates with the decrease in transgene expression in the periphery as mice age

decreased T cell proliferation ( J:128694 )

• the proliferative response of splenic T cells in response to T cell receptor plus CD28 stimulation is reduced

cellular

decreased T cell proliferation ( J:128694 )

• the proliferative response of splenic T cells in response to T cell receptor plus CD28 stimulation is reduced