Phenotypes Associated with This Genotype

Genotype
MGI:3769347

• Allelic Composition: Jak3^tm1Ljb/Jak3^tm1Ljb; Tg(Lck-Jak3)2Ljb/0
• Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:56629 )

N • unlike in homozygous null mice that do not express the transgene, the numbers of CD4 and CD8 cells in the spleen and thymus are normal

enlarged spleen ( J:56629 )

• splenomegaly apparent after 12 weeks of age

• spleen size is 2 to 3 times that of age-matched homozygous null mice that do not express the transgene

increased leukocyte cell number ( J:56629 )

• an expansion of large granular cells is seen, similar to homozygous null mice that do not express the transgene

abnormal T cell activation ( J:56629 )

• CD4+ cells show an activated phenotype

hematopoietic system

enlarged spleen ( J:56629 )

• splenomegaly apparent after 12 weeks of age

• spleen size is 2 to 3 times that of age-matched homozygous null mice that do not express the transgene

increased leukocyte cell number ( J:56629 )

• an expansion of large granular cells is seen, similar to homozygous null mice that do not express the transgene

abnormal T cell activation ( J:56629 )

• CD4+ cells show an activated phenotype

growth/size/body

enlarged spleen ( J:56629 )

• splenomegaly apparent after 12 weeks of age

• spleen size is 2 to 3 times that of age-matched homozygous null mice that do not express the transgene