Phenotypes Associated with This Genotype

Genotype
MGI:3769119

• Allelic Composition: Irf1^tm1Mak/Irf1^tm1Mak
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:115104 )

N • apoptosis following UV-induced damage is similar in mutant primary hepatocytes from 6-10 week males and wild-type cells

N • 6-12 hours after UV irradiation, hepatocytes arrest in at G₁/S, similar to wild-type cells

impaired DNA repair ( J:115104 )

• cultured hepatocytes from 6-10 week males show a defect in DNA repair in an assay in which repair of a UV-damaged reporter plasmid by wild-type and null hepatocytes; recovery of reporter activity by Irf1-deficient hepatocytes is significantly lower than that of wild-type or Trp53-deficient cells

homeostasis/metabolism

impaired DNA repair ( J:115104 )

• cultured hepatocytes from 6-10 week males show a defect in DNA repair in an assay in which repair of a UV-damaged reporter plasmid by wild-type and null hepatocytes; recovery of reporter activity by Irf1-deficient hepatocytes is significantly lower than that of wild-type or Trp53-deficient cells