Phenotypes Associated with This Genotype

Genotype
MGI:3769028

• Allelic Composition: Cigs2^tm1.1Kubo/Cigs2^tm1.1Kubo
• Genetic Background: B6.Cg-Cigs2^tm1.1Kubo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal mast cell physiology ( J:129048 )

• bone marrow-derived mast cells produce less IL-4 and IL-13 but not IL-3 or IL-6 in response to Iono compared to wild-type mice

abnormal neutrophil physiology ( J:129048 )

• polymorphonuclear cells produce less IL-4 and IL-13 in response to Iono than wild-type cells and 200 times less IL-4 than bone marrow-derived mast cells

abnormal interleukin secretion ( J:129048 )

• bone marrow-derived mast cells produce less IL-4 and IL-13 but not IL-3 or IL-6 in response to Iono compared to wild-type mice

• polymorphonuclear cells produce less IL-4 and IL-13 in response to Iono than wild-type cells and 200 times less IL-4 than bone marrow-derived mast cells

• however, basophils from the bone marrow produce normal amounts of cytokines in response to IL3

decreased interleukin-13 secretion ( J:129048 )

decreased interleukin-4 secretion ( J:129048 , J:167446 )

• in CD4+ T cells (J:167446)

hematopoietic system

abnormal mast cell physiology ( J:129048 )

• bone marrow-derived mast cells produce less IL-4 and IL-13 but not IL-3 or IL-6 in response to Iono compared to wild-type mice

abnormal neutrophil physiology ( J:129048 )

• polymorphonuclear cells produce less IL-4 and IL-13 in response to Iono than wild-type cells and 200 times less IL-4 than bone marrow-derived mast cells