Phenotypes Associated with This Genotype

Genotype
MGI:3769002

• Allelic Composition: Fgf3^tm1.1Sms/Fgf3^tm1.1Sms
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:128377 )

• at weaning, only 9% of heterozygous intercross offspring were homozygous mutant, indicating significant lethality associated with this allele

limbs/digits/tail

short tail ( J:128377 )

curly tail ( J:128377 )

hearing/vestibular/ear

dilated cochlea ( J:128377 )

• showed only rudimentary partitioning into distended cochlear chamber

abnormal scala vestibuli morphology ( J:128377 )

• showed only rudimentary partitioning into distended vestibular chamber

decreased cochlea coiling ( J:128377 )

• the swollen cochlear duct showed incomplete partition and poor coiling

absent common crus ( J:128377 )

absent posterior semicircular canal ( J:128377 )

• absence or severe truncation of the anterior and posterior semicircular canals in some

absent superior semicircular canal ( J:128377 )

• absence or severe truncation of the anterior and posterior semicircular canals in some

abnormal membranous labyrinth morphology ( J:128377 )

• all affected mutant ears had a distended membranous labyrinth

dilated scala media ( J:128377 )

abnormal utricle morphology ( J:128377 )

• fusion of utricle and saccule

abnormal vestibular saccule morphology ( J:128377 )

• fusion of utricle and saccule

absent endolymphatic sac ( J:128377 )

short endolymphatic duct ( J:128377 )

increased or absent threshold for auditory brainstem response ( J:128377 )

• significantly elevated ABR thresholds in one or both ears

behavior/neurological

head tilt ( J:128377 )

• a light head tilt were seen in mice showing significant ABR threshold increase only in one ear

circling ( J:128377 )

• in mice showing significant ABR threshold increase in bilateral ears