Phenotypes Associated with This Genotype

Genotype
MGI:3768686

• Allelic Composition: Tgfb3^tm2(Tgfb1)Vk/Tgfb3^tm2(Tgfb1)Vk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:128938 )

• pups do not survive past two weeks of age

craniofacial

abnormal palatal shelf fusion at midline ( J:128938 )

• shelves do not fuse at the most anterior and posterior regions of the palate

• reduced apoptosis occurs in the midline epithelium during fusion

cleft palate ( J:128938 )

• clefts occur at the junction of the primary and secondary palates and in the posterior region of E17 embryos

abnormal nasal septum morphology ( J:128938 )

• the nasal septum fails to fuse with the anterior palate in E17 embryos

behavior/neurological

abnormal suckling behavior ( J:128938 )

• pups fail to suckle

digestive/alimentary system

abnormal palatal shelf fusion at midline ( J:128938 )

• shelves do not fuse at the most anterior and posterior regions of the palate

• reduced apoptosis occurs in the midline epithelium during fusion

cleft palate ( J:128938 )

• clefts occur at the junction of the primary and secondary palates and in the posterior region of E17 embryos

respiratory system

abnormal nasal septum morphology ( J:128938 )

• the nasal septum fails to fuse with the anterior palate in E17 embryos

growth/size/body

abnormal palatal shelf fusion at midline ( J:128938 )

• shelves do not fuse at the most anterior and posterior regions of the palate

• reduced apoptosis occurs in the midline epithelium during fusion

cleft palate ( J:128938 )

• clefts occur at the junction of the primary and secondary palates and in the posterior region of E17 embryos

abnormal nasal septum morphology ( J:128938 )

• the nasal septum fails to fuse with the anterior palate in E17 embryos