Phenotypes Associated with This Genotype

Genotype
MGI:3768656

• Allelic Composition: Tg(Prp-GPR37)1Ryot/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

loss of dopaminergic neurons ( J:140326 )

• mild

neuron degeneration ( J:128745 )

• TH+ neurons in the substantia nigra, ventral tegmental area and the locus coeruleus exhibit an age-dependent loss

abnormal neuron physiology ( J:128745 )

• the input resistance of dopamine neurons is slightly larger that in non-transgenic mice

• the input resistance in the striatal motorsensory neurons is larger than in non-transgenic mice

increased susceptibility to dopaminergic neuron neurotoxicity ( J:128745 )

• mice exhibit a 64% reduction in TH+ neurons when treated with the dopamine neurotoxin MPTP compared to 16% in non-transgenic mice

• dopamine levels exhibit a 38% reduction 3 weeks after treatment with the dopamine neurotoxin 6-OHDA compared to an 81% reduction in wild-type mice

behavior/neurological

abnormal motor coordination/balance ( J:128745 )

• mice exhibit increased performance in a rotarod test compared to wild-type mice

hyperactivity ( J:128745 )

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:128745 )

• mice exhibit a 64% reduction in TH+ neurons when treated with the dopamine neurotoxin MPTP compared to 16% in non-transgenic mice

• dopamine levels exhibit a 38% reduction 3 weeks after treatment with the dopamine neurotoxin 6-OHDA compared to an 81% reduction in wild-type mice

increased dopamine level ( J:128745 )

• DOPAC and vesicular dopamine levels are increased in the striatum compared to in wild-type mice

• dopamine storage and release is increased

growth/size/body

slow postnatal weight gain ( J:128745 )

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:128745 )

• mice exhibit a 64% reduction in TH+ neurons when treated with the dopamine neurotoxin MPTP compared to 16% in non-transgenic mice

• dopamine levels exhibit a 38% reduction 3 weeks after treatment with the dopamine neurotoxin 6-OHDA compared to an 81% reduction in wild-type mice

oxidative stress ( J:140326 )

• mice exhibit an age-dependent increase in the levels of a marker of oxidative damage in the midbrain region

• however, mice do exhibit oxidative damage in the cortex region