Phenotypes Associated with This Genotype

Genotype
MGI:3768652

• Allelic Composition: Tg(Tyr-NRAS*Q61K)1Bee/?
• Genetic Background: involves: C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal melanocyte morphology ( J:98545 )

• melanocytes in the papillary dermis while few melanocytes are found within the interfollicular epidermis and the hair follicles

hyperpigmentation ( J:98545 )

• mice exhibit hyperpigmentation of the skin, paws, ears and tail

• mice exhibit a band-like distribution of pigmented

vision/eye

abnormal optic choroid morphology ( J:98545 )

• the choroidal layer is thickened resulting in a folding of the neuroretina in adult mice

immune system

skin inflammation ( J:98545 )

integument

skin inflammation ( J:98545 )

abnormal hair follicle morphology ( J:98545 )

• hair follicle architecture is occasionally disrupted

• numerous melanocytes are found in the epithelium of the upper, permanent, portion of the hair follicle and seem to disrupt follicles during anagen

abnormal dermis papillary layer morphology ( J:98545 )

• melanocytes are present in the papillary dermis

abnormal dermis reticular layer morphology ( J:98545 )

• melanin-containing macrophages are found within the reticular dermis and subcutaneous fat

hyperkeratosis ( J:98545 )

• in some mice

epidermal hyperplasia ( J:98545 )

• in some mice

thick epidermis ( J:98545 )

• in some mice