Phenotypes Associated with This Genotype

Genotype
MGI:3768548

• Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:128732 )

• mice exhibit grip weakness when tested on an inverted grid and show shortened ledge retention time compared to wild-type mice

weakness ( J:128732 )

nervous system

abnormal nervous system electrophysiology ( J:144561 )

• most Purkinje neurons lack spontaneous and tonic firing

• however, individual action potential waveforms in Purkinje cells and evoked excitatory postsynaptic currents (EPSCs) in Purkinje neurons are similar to wild-type mice

abnormal CNS synaptic transmission ( J:128732 )

• granule neuron excitability is impaired