Phenotypes Associated with This Genotype

Genotype
MGI:3768547

• Allelic Composition: Fgf12^tm1Gol/Fgf12^tm1Gol; Fgf14^tm1Dor/Fgf14^tm1Dor
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal response to new environment ( J:128732 )

• mice exhibit increased activity when placed in a new environment

ataxia ( J:128732 )

• severe

decreased grip strength ( J:128732 )

• mice fall off a grid when titled at a 45 degree angle and do not pull a rod with any measurable force when pulled backwards by their tails

weakness ( J:128732 )

abnormal gait ( J:128732 )

hyperactivity ( J:128732 )

• mice exhibit increased activity when disturbed or placed in a new environment

nervous system

abnormal CNS synaptic transmission ( J:128732 )

• granule neuron excitability is more severely impaired than in Fgf14^tm1Dor mice (1 firing compared to 2 in Fgf14^tm1Dor mice)

abnormal channel response ( J:128732 )

• sodium channel inactivation parameters are altered in cerebellar granule neurons