Phenotypes Associated with This Genotype

Genotype
MGI:3768544

• Allelic Composition: Chn1^tm2Abet/Chn1^tm2Abet
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

tonic seizures ( J:128724 )

abnormal axon extension ( J:128724 )

• fewer growth cones collapse in culture when neurons are treated with Efnb3 or Efna1 compared to in wild-type cultures

enlarged brain ventricles ( J:128724 )

• some ventricles are enlarged

behavior/neurological

abnormal gait ( J:128724 )

• at the onset of locomotion mice display a rabbit-like hopping gait

tonic seizures ( J:128724 )

growth/size/body

decreased body size ( J:128724 )

• shortly after birth mice are smaller than wild-type but reach normal size by adulthood

cellular

abnormal axon extension ( J:128724 )

• fewer growth cones collapse in culture when neurons are treated with Efnb3 or Efna1 compared to in wild-type cultures