Phenotypes Associated with This Genotype

Genotype
MGI:3768542

• Allelic Composition: Bmp2^tm1Cjt/Bmp2^tm1Cjt; Bmp7^tm1Rob/Bmp7^tm1Rob; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects

limbs/digits/tail

abnormal phalanx morphology ( J:118257 )

• the last phalanx is missing from digit III in the forelimb and sometimes from the hindlimb

abnormal fibula morphology ( J:118257 )

• fibulae of hindlimbs are malformed and do not articulate with the femur at the knee

skeleton

abnormal appendicular skeleton morphology ( J:118257 )

• overall size of the appendicular skeleton is slightly diminished

abnormal phalanx morphology ( J:118257 )

• the last phalanx is missing from digit III in the forelimb and sometimes from the hindlimb

abnormal fibula morphology ( J:118257 )

• fibulae of hindlimbs are malformed and do not articulate with the femur at the knee

abnormal scapula morphology ( J:118257 )

• scapular defect