Phenotypes Associated with This Genotype

Genotype
MGI:3768252

• Allelic Composition: Heph^sla/Y
• Genetic Background: B6.Cg-Heph^sla

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal iron homeostasis ( J:5660 )

♂ • in the duodenum crypt cells of male mice, the amount of iron deposited after intravenous iron administration is greater than normal, either because of increased avidity or decreased return to plasma

abnormal iron level ( J:6052 )

♂ • total body iron is decreased

hematopoietic system

anemia ( J:6052 )

♂

decreased hemoglobin content ( J:6052 )

♂

embryo

abnormal placental transport ( J:6052 )

♂ • defect in placental iron transport; when iron is administered continuously in food of pregnant females, a significant reduction in iron transfer to mutant male fetuses is observed compared to transfer to heterozygous or wild-type male fetuses