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Phenotypes Associated with This Genotype
Genotype
MGI:3768115
Allelic
Composition
Dnajc5tm1Sud/Dnajc5tm1Sud
Tg(THY1-SNCA*A30P)TS2Sud/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnajc5tm1Sud mutation (2 available); any Dnajc5 mutation (24 available)
Tg(THY1-SNCA*A30P)TS2Sud mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• lethality is similar to that observed for Dnajc5-deficient mice

growth/size/body
• mice exhibit relative loss of body weight after P20 similar to non-transgenic Dnajc5-deficient littermates

behavior/neurological
• mice fail behavioral tests requiring vision
• mice show similar impairment to that seen for Dnajc5-deficient mice; transgene expression does not rescue righting ability
• expression of mutant human SNCA only partially rescues ataxia observed in Dnajc5-deficient mice
• in a grip test, mice cannot grip the mesh for very long before dropping, compared to the 2 minute duration of the test achieved by wild-type mice

nervous system
• mice show considerable photoreceptor degeneration

vision/eye
• mice show considerable photoreceptor degeneration
• ONL shrinks dramatically with photoreceptor degeneration
• OPL disintegrates in mutants


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory