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Phenotypes Associated with This Genotype
Genotype
MGI:3767957
Allelic
Composition		 Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc6tm1Gvh mutation (1 available); any Ercc6 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Microglia activation in the white matter in Ercc2, Ercc6, and Ercc8 mutants

cellular
astrocytosis ( J:179808 )
• in the white matter
microgliosis ( J:179808 )
• in the white matter

growth/size/body
postnatal growth retardation ( J:122013 )

vision/eye

nervous system
astrocytosis ( J:179808 )
• in the white matter
microgliosis ( J:179808 )
• in the white matter

hematopoietic system
microgliosis ( J:179808 )
• in the white matter

immune system
microgliosis ( J:179808 )
• in the white matter

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory