Phenotypes Associated with This Genotype

Genotype
MGI:3767818

• Allelic Composition: Fezf1^tm1Hibi/Fezf1^tm1Hibi; Fezf2^tm1Hibi/Fezf2^tm1Hibi
• Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal diencephalon morphology ( J:119561 )

• at E18.5, the habenulo-intepeduncular tracts are small and abnormally located and the mammilothalamic tract is absent

• however, pretectum development is normal

• at E12.5, the prethalamus is absent and the caudal diencephalon is expanded

• at E10.5, regionalization of the diencephalons is defective

small thalamus ( J:119561 )

• the prethalamus is absent and the thalamus is reduced in size

abnormal hippocampus CA3 region morphology ( J:119561 )

• the CA3 region is strongly reduced

absent dentate gyrus ( J:119561 )

• the dentate gyrus is absent

abnormal neocortex morphology ( J:119561 )

• formation of the neocortex is impaired

small olfactory bulb ( J:119561 )

• the olfactory bulb is nearly completely lost