Phenotypes Associated with This Genotype

Genotype
MGI:3767787

• Allelic Composition: Tg(CAG-AR*97Q)7-8Sobue/?; Tg(CAG-STUB1)1Sobue/Tg(CAG-STUB1)1Sobue
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:121559 )

• motor coordination impairment on a rotarod test is not as sever as in Tg(ACTB-AR*97Q)2-6Sobu male mice but not as improved as in Tg(ACTB-STUB1)Sobu/Tg(ACTB-STUB1)Sobu Tg(ACTB-AR*97Q)2-6Sobu male mice

• male mice took smaller steps when walking than Tg(ACTB-STUB1)Sobu/Tg(ACTB-STUB1)Sobu Tg(ACTB-AR*97Q)2-6Sobu male but longer than Tg(ACTB-AR*97Q)2-6Sobu male mice

muscle

muscular atrophy ( J:121559 )

• muscular atrophy in male mice is less than in Tg(ACTB-AR*97Q)2-6Sobu male mice

growth/size/body

weight loss ( J:121559 )

• male mice do not lose as much weight as quickly as Tg(ACTB-AR*97Q)2-6Sobu mice