Phenotypes Associated with This Genotype

Genotype
MGI:3767626

• Allelic Composition: a^e/a^e; Tbx15^de-H/Tbx15^de-H
• Genetic Background: involves: BTBR * C3H/HeJ * C57BL/6 * P * S

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dorsal skin pigmentation of Tbx15^de-H/Tbx15^de-H neonates

growth/size/body

decreased body size ( J:87455 )

pigmentation

abnormal skin pigmentation ( J:87455 )

• the extent of dorsal skin pigmentation is reduced in neonates; unlike in a^e mice where neonatal skin appears uniformly dark over the entire dorsum, in double mutants, the area of dark skin is more restricted, particularly above the limbs and resembles the pattern of dorsal eumelanin in a^t Tbx15^de-H double homozygous mutants

skeleton

abnormal skeleton morphology ( J:87455 )

• skeletal abnormalities

integument

integument phenotype ( J:87455 )

N • display no coat-color phenotype

short hair ( J:87455 )

• small but consistent reduction in hair length in both dorsum and ventrum; reduced hair is most apparent in the lateral region

abnormal skin pigmentation ( J:87455 )

• the extent of dorsal skin pigmentation is reduced in neonates; unlike in a^e mice where neonatal skin appears uniformly dark over the entire dorsum, in double mutants, the area of dark skin is more restricted, particularly above the limbs and resembles the pattern of dorsal eumelanin in a^t Tbx15^de-H double homozygous mutants