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Phenotypes Associated with This Genotype
Genotype
MGI:3767321
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (56 available); any Rag1 mutation (132 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• dextran sulfate sodium induced colitis is less severe than in wild-type controls
• 2 weeks or 1 month after infection with M. pulmonis, neutrophil numbers in the trachea are elevated above uninfected controls but are significantly lower than numbers in trachea of infected wild-type mice
• upon infection with Mycoplasma pulmonis, airway lymphatic vessel remodeling is largely absent from mutants, compared to significant invasion of region by lymphatic vessels in infected wild-type mice
• antigen-specific autoimmunity developed after CD4-selected splenocytes from Tg(Tcra,Tcrb)9Rest donor mice
• airway vascular and airway lymphatic vessel remodeling are impaired or absent compared to wild-type mice after M. pulmonis infection

hematopoietic system
• 2 weeks or 1 month after infection with M. pulmonis, neutrophil numbers in the trachea are elevated above uninfected controls but are significantly lower than numbers in trachea of infected wild-type mice

respiratory system
• after 4 weeks, mice show impaired vascular remodeling of the airways in response to Mycoplasma pulmonis infection whereas wild-type show complex growth and reorganization ot the vascular beds

pigmentation
• after transplant of CD4-selected splenocytes, mice develop extensive vitiligo
• after transplant of CD4-selected splenocytes, mice develop extensive vitiligo

vision/eye
• mice develop ocular injury with disruption of retinal architecture after transplant of CD4-selected splenocytes from Tg(Tcra,Tcrb)9Rest/Rag1--mice
• mice develop ocular injury with disruption of retinal architecture after transplant of CD4-selected splenocytes from Tg(Tcra,Tcrb)9Rest/Rag1--mice

integument
• after transplant of CD4-selected splenocytes, mice develop extensive vitiligo
• after transplant of CD4-selected splenocytes, mice develop extensive vitiligo

digestive/alimentary system
• dextran sulfate sodium induced colitis is less severe than in wild-type controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory