immune system
• dextran sulfate sodium induced colitis is less severe than in wild-type controls
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• 2 weeks or 1 month after infection with M. pulmonis, neutrophil numbers in the trachea are elevated above uninfected controls but are significantly lower than numbers in trachea of infected wild-type mice
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• upon infection with Mycoplasma pulmonis, airway lymphatic vessel remodeling is largely absent from mutants, compared to significant invasion of region by lymphatic vessels in infected wild-type mice
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• antigen-specific autoimmunity developed after CD4-selected splenocytes from Tg(Tcra,Tcrb)9Rest donor mice
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• airway vascular and airway lymphatic vessel remodeling are impaired or absent compared to wild-type mice after M. pulmonis infection
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hematopoietic system
• 2 weeks or 1 month after infection with M. pulmonis, neutrophil numbers in the trachea are elevated above uninfected controls but are significantly lower than numbers in trachea of infected wild-type mice
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respiratory system
• after 4 weeks, mice show impaired vascular remodeling of the airways in response to Mycoplasma pulmonis infection whereas wild-type show complex growth and reorganization ot the vascular beds
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pigmentation
• after transplant of CD4-selected splenocytes, mice develop extensive vitiligo
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• after transplant of CD4-selected splenocytes, mice develop extensive vitiligo
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vision/eye
• mice develop ocular injury with disruption of retinal architecture after transplant of CD4-selected splenocytes from Tg(Tcra,Tcrb)9Rest/Rag1--mice
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• mice develop ocular injury with disruption of retinal architecture after transplant of CD4-selected splenocytes from Tg(Tcra,Tcrb)9Rest/Rag1--mice
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integument
• after transplant of CD4-selected splenocytes, mice develop extensive vitiligo
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• after transplant of CD4-selected splenocytes, mice develop extensive vitiligo
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digestive/alimentary system
• dextran sulfate sodium induced colitis is less severe than in wild-type controls
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