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Phenotypes Associated with This Genotype
Genotype
MGI:3767256
Allelic
Composition		 Rorctm1Litt/Rorctm1Litt
Tcra-Jtm3.1Krg/Tcra-Jtm3.1Krg
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rorctm1Litt mutation (1 available); any Rorc mutation (42 available)
Tcra-Jtm3.1Krg mutation (0 available); any Tcra-J mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:128344 )
• unlike in Rorctm1Litt homozygotes, primary rearrangement of 5' Jalpha segments is completely abolished (0.5% compared to 54% in Rorctm1Litt homozygotes) while rearrangement of the central Jalpha segments is increased (54.8% compared to 18.2% in Rorctm1Litt homozygotes)

immune system
abnormal T cell differentiation ( J:128344 )
• unlike in Rorctm1Litt homozygotes, primary rearrangement of 5' Jalpha segments is completely abolished (0.5% compared to 54% in Rorctm1Litt homozygotes) while rearrangement of the central Jalpha segments is increased (54.8% compared to 18.2% in Rorctm1Litt homozygotes)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory