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Phenotypes Associated with This Genotype
Genotype
MGI:3767204
Allelic
Composition
Hephsla/Hephsla
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hephsla mutation (1 available); any Heph mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• reduction in hematopoietic tissue in both the liver and bone marrow
• anemia is most severe at a young age and tends to diminish with increasing age
• iron-dextran injection resolves the anemia
• red blood cell count is reduced to about 3/4 of the normal value (J:64261)
(J:128474)
• slight reduction in mean cell volume
• erythrocytes show great variation in size and form
• some cells are macrocytic
• many microcytic cells
• macrocytic cells with marked polychromasia


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory