Phenotypes Associated with This Genotype

Genotype
MGI:3766576

• Allelic Composition: Tg(Myh6-Map2k1*)1Jmol/?
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiac output ( J:127872 )

• 7 days after ischemia injury, mice have no loss of cardiac output compared to 50% loss in wild-type controls

decreased myocardial infarct size ( J:127872 )

• there is two-third less infarction of the left ventricular area after ischemia/reperfusion injury

muscle

decreased cardiomyocyte apoptosis ( J:127872 )

• eight fold less cardiomyocytes are undergoing apoptosis 24 hours after ischemia/reperfusion injury

homeostasis/metabolism

decreased myocardial infarct size ( J:127872 )

• there is two-third less infarction of the left ventricular area after ischemia/reperfusion injury

cellular

decreased cardiomyocyte apoptosis ( J:127872 )

• eight fold less cardiomyocytes are undergoing apoptosis 24 hours after ischemia/reperfusion injury