Phenotypes Associated with This Genotype

Genotype
MGI:3766501

• Allelic Composition: Tg(Myh6-Map2k1*)1Jmol/?
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:66102 )

• about 30% increase in the cross-sectional area of each myocardial fiber

heart left ventricle hypertrophy ( J:66102 )

• there is about a 50% increase left ventricular posterior wall thickness

increased heart weight ( J:66102 )

• increased heart:body weight ratio of 34, 41, and 23% is observed at 3 weeks, 8 weeks, and 6 months of age

thick ventricular wall ( J:66102 )

• there is about a 50% increase in septal thickness and left ventricular posterior wall thickness

decreased left ventricle diastolic pressure ( J:66102 )

• diastolic function is reduced due to decreased ventricular volume

increased left ventricle systolic pressure ( J:66102 )

• greater than 10% increase in left ventricular systolic pressure

muscle

increased myocardial fiber size ( J:66102 )

• about 30% increase in the cross-sectional area of each myocardial fiber

heart left ventricle hypertrophy ( J:66102 )

• there is about a 50% increase left ventricular posterior wall thickness

decreased cardiomyocyte apoptosis ( J:66102 )

• less apoptosis is observed in mice subjected to ischemia/reperfusion of the left coronary artery

cellular

decreased cardiomyocyte apoptosis ( J:66102 )

• less apoptosis is observed in mice subjected to ischemia/reperfusion of the left coronary artery

growth/size/body

heart left ventricle hypertrophy ( J:66102 )

• there is about a 50% increase left ventricular posterior wall thickness

increased heart weight ( J:66102 )

• increased heart:body weight ratio of 34, 41, and 23% is observed at 3 weeks, 8 weeks, and 6 months of age