Phenotypes Associated with This Genotype

Genotype
MGI:3766083

• Allelic Composition: Tg(Ins2-Lta)#Flv/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mononuclear cell infiltration in islets of Tg(Ins2-Lta)#Flv/0 mice

immune system

insulitis ( J:127705 )

• apparent in transgenic animals, but not in non-transgenic littermates; some islets are partially or completely infiltrated with mononuclear cells

• 30-45% of islets in mice 1-5 months of age do not have apparent infiltration

• ~10% of islets show insulitis or periinsulitis in 1 month old mice, with 30-45% of islets affected in 5-month old animals

periinsulitis ( J:127705 )

• apparent in transgenic animals, but not in non-transgenic littermates; some islets show interstitial accumulation of mononuclear cells around the islet capsule without obvious infiltration

endocrine/exocrine glands

insulitis ( J:127705 )

• apparent in transgenic animals, but not in non-transgenic littermates; some islets are partially or completely infiltrated with mononuclear cells

• 30-45% of islets in mice 1-5 months of age do not have apparent infiltration

• ~10% of islets show insulitis or periinsulitis in 1 month old mice, with 30-45% of islets affected in 5-month old animals

periinsulitis ( J:127705 )

• apparent in transgenic animals, but not in non-transgenic littermates; some islets show interstitial accumulation of mononuclear cells around the islet capsule without obvious infiltration