Phenotypes Associated with This Genotype

Genotype
MGI:3766050

• Allelic Composition: Del(4Cdkn2a-Cdkn2b)2Brn/+
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:125189 )

• within 7 months mice develop one or more tumors

• tumors are often composed of different cell types and frequently show biphasic morphology

increased intestinal adenocarcinoma incidence ( J:125189 )

• a few mice develop adenocarcinoma of the intestinal tract

increased skin tumor incidence ( J:125189 )

• within 7 months mice develop one or more tumor that are predominantly skin tumor such as squamous cell carcinoma, basal cell carcinoma and tricho-epithelioma/hair-germ-cell tumors

increased leukemia incidence ( J:125189 )

• several mice develop lymphoma and leukemia

increased lymphoma incidence ( J:125189 )

• several mice develop lymphoma and leukemia

increased melanoma incidence ( J:125189 )

• one mouse develops spontaneous melanoma at 3 weeks of age

increased sarcoma incidence ( J:125189 )

• within 7 months mice develop one or more tumor including various soft tissue sarcomas

integument

increased skin tumor incidence ( J:125189 )

• within 7 months mice develop one or more tumor that are predominantly skin tumor such as squamous cell carcinoma, basal cell carcinoma and tricho-epithelioma/hair-germ-cell tumors

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:125189 )

• a few mice develop adenocarcinoma of the intestinal tract