mortality/aging
• diabetes-like symptoms (dehydration, weight loss) lead to death of most animals by 6 months of age
|
growth/size/body
weight loss
(
J:93555
)
immune system
• mice develop clinical signs of diabetes
|
endocrine/exocrine glands
• islet architecture becomes disorganized and islet tissue is replace by a ductal hyperplasia
|
homeostasis/metabolism
dehydration
(
J:93555
)