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Phenotypes Associated with This Genotype
Genotype
MGI:3766042
Allelic
Composition
Tg(Ins2-CD80)3B7Flv/0
Tg(Ins2-H2-Ead,Ins2-H2-Eb1b)187-7Bri/0
Genetic
Background
involves: C57BL/6 * CBA/Ca * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-CD80)3B7Flv mutation (5 available)
Tg(Ins2-H2-Ead,Ins2-H2-Eb1b)187-7Bri mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• diabetes-like symptoms (dehydration, weight loss) lead to death of most animals by 6 months of age

growth/size/body

immune system
• mice develop insulitis starting at ~5 months of age
• mice develop clinical signs of diabetes

endocrine/exocrine glands
• islet architecture becomes disorganized and islet tissue is replace by a ductal hyperplasia
• mice develop insulitis starting at ~5 months of age

homeostasis/metabolism


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory