Phenotypes Associated with This Genotype

Genotype
MGI:3766040

• Allelic Composition: Tg(Ins2-CD86)12B70Flv/0; Tg(Ins2-H2-Ea^d,Ins2-H2-Eb1^b)187-7Bri/0
• Genetic Background: involves: C57BL/6 * CBA/Ca * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:93555 )

• diabetes-like symptoms (dehydration, weight loss) lead to death of most animals by 6 months of age

growth/size/body

weight loss ( J:93555 )

immune system

insulitis ( J:93555 )

• double mutants develop insulitis at 2 months of age

abnormal cytokine secretion ( J:93555 )

• mice have a greater number of cytokine-positive cells (Il4 or Ifng) compared to mice coexpressing CD80 and the MHC class II transgene

increased susceptibility to autoimmune diabetes ( J:93555 )

• mice develop clinical signs of diabetes

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:93555 )

• mice show autoimmune destruction of pancreatic beta cells

insulitis ( J:93555 )

• double mutants develop insulitis at 2 months of age

homeostasis/metabolism

increased circulating glucose level ( J:93555 )

• mice show elevated blood glucose levels (363 mg/dl at 8 weeks rising to 402 mg/dl at 6 months)

dehydration ( J:93555 )