Phenotypes Associated with This Genotype

Genotype
MGI:3766036

• Allelic Composition: Tg(Ins2-CD86)12B70Flv/0
• Genetic Background: involves: C57BL/6 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

periinsulitis ( J:93555 )

• mice do not display any autoimmune pathology until 7 months of age; at ~7-8 months, mice develop a perivascular/periductal (peri-islet) infiltration; by 14 months of age, infiltrate has not progressed to insulitis or diabetes

abnormal cytokine secretion ( J:93555 )

• there are 3-10 times more Il4-positive cells than Ifng-positive cells in islet infiltrates; an increased accumulation of Il4-positive cells in pancreatic infiltrates is observed as mice age

decreased susceptibility to autoimmune diabetes ( J:93555 )

• transgenic mice do not develop autoimmune diabetes

endocrine/exocrine glands

periinsulitis ( J:93555 )

• mice do not display any autoimmune pathology until 7 months of age; at ~7-8 months, mice develop a perivascular/periductal (peri-islet) infiltration; by 14 months of age, infiltrate has not progressed to insulitis or diabetes