Mouse Genome Informatics
tg
    Tg(Ins2-CD86)12B70Flv/0
involves: C57BL/6 * CBA/Ca
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• mice do not display any autoimmune pathology until 7 months of age; at ~7-8 months, mice develop a perivascular/periductal (peri-islet) infiltration; by 14 months of age, infiltrate has not progressed to insulitis or diabetes
• there are 3-10 times more Il4-positive cells than Ifng-positive cells in islet infiltrates; an increased accumulation of Il4-positive cells in pancreatic infiltrates is observed as mice age
• transgenic mice do not develop autoimmune diabetes

endocrine/exocrine glands
• mice do not display any autoimmune pathology until 7 months of age; at ~7-8 months, mice develop a perivascular/periductal (peri-islet) infiltration; by 14 months of age, infiltrate has not progressed to insulitis or diabetes

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:93555