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Phenotypes Associated with This Genotype
Genotype
MGI:3766036
Allelic
Composition
Tg(Ins2-CD86)12B70Flv/0
Genetic
Background
involves: C57BL/6 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-CD86)12B70Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice do not display any autoimmune pathology until 7 months of age; at ~7-8 months, mice develop a perivascular/periductal (peri-islet) infiltration; by 14 months of age, infiltrate has not progressed to insulitis or diabetes
• there are 3-10 times more Il4-positive cells than Ifng-positive cells in islet infiltrates; an increased accumulation of Il4-positive cells in pancreatic infiltrates is observed as mice age
• transgenic mice do not develop autoimmune diabetes

endocrine/exocrine glands
• mice do not display any autoimmune pathology until 7 months of age; at ~7-8 months, mice develop a perivascular/periductal (peri-islet) infiltration; by 14 months of age, infiltrate has not progressed to insulitis or diabetes

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:93555


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory