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Phenotypes Associated with This Genotype
Genotype
MGI:3766015
Allelic
Composition		 Raratm1Ipc/Raratm1Ipc
Rarbtm1Mma/Rarb+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raratm1Ipc mutation (1 available); any Rara mutation (77 available)
Rarbtm1Mma mutation (0 available); any Rarb mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal skeleton morphology ( J:43344 )
• 100% of mutants show skeletal malformations
abnormal temporal bone squamous part morphology ( J:43344 )
• 11 of 14 mutants exhibit malformed squamosal bone
abnormal incus morphology ( J:43344 )
• 7 of 14 mutants exhibit a pterygoquadrate element
abnormal thyroid cartilage morphology ( J:43344 )
• 1 of 15 (7%) mutants shows thyroid cartilage fused to hyoid bone
abnormal tracheal cartilage morphology ( J:43344 )
• 3 of 15 (20%) mutants show tracheal cartilage malformations
fusion of atlas and odontoid process ( J:43344 )
• 8 of 15 (53%) mutants show fusion of C1-AA with C2 dens
split cervical atlas ( J:43344 )
• 3 of 15 (20%) mutants show a bifid C1
split cervical axis ( J:43344 )
• 5 of 15 (33%) mutants show a bifid C2
fusion of vertebral arches ( J:43344 )
• 2 of 15 (13%) mutants show fusions of neural arches of C2 and C3
thoracic vertebral transformation ( J:43344 )
• 6 of 15 (40%) mutants show anterior transformation of L1 to T14
cervical vertebral transformation ( J:43344 )
• 3 of 15 (20%) mutants show anterior transformation of C2 to C1

hearing/vestibular/ear
abnormal incus morphology ( J:43344 )
• 7 of 14 mutants exhibit a pterygoquadrate element

craniofacial
abnormal temporal bone squamous part morphology ( J:43344 )
• 11 of 14 mutants exhibit malformed squamosal bone
abnormal incus morphology ( J:43344 )
• 7 of 14 mutants exhibit a pterygoquadrate element

respiratory system
abnormal thyroid cartilage morphology ( J:43344 )
• 1 of 15 (7%) mutants shows thyroid cartilage fused to hyoid bone
abnormal tracheal cartilage morphology ( J:43344 )
• 3 of 15 (20%) mutants show tracheal cartilage malformations

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory