Phenotypes Associated with This Genotype

Genotype
MGI:3766014

• Allelic Composition: Rarg^tm1Ipc/Rarg^tm1Ipc
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal skeleton morphology ( J:43344 )

• 100% of mutants show skeletal malformations

abnormal basioccipital bone morphology ( J:43344 )

• 2 of 12 (17%) mutants exhibit a posterior tubercle on the basioccipital bone

absent metoptic pillar ( J:43344 )

• 11 of 15 mutants exhibit agenesis of the metoptic pillar

fusion of atlas and occipital bones ( J:43344 )

• 1 of 12 (8%) show fusion of the basioccipital bone with C1-AA

abnormal tracheal cartilage morphology ( J:43344 )

• 11 of 12 (92%) mutants show tracheal cartilage abnormalities

thoracic vertebral transformation ( J:43344 )

• 5 of 12 (42%) mutants show anterior transformation of T8 to T7

fusion of atlas and odontoid process ( J:43344 )

• 3 of 12 (25%) mutants show fusion of C1-AA with C2 dens

split cervical atlas ( J:43344 )

• 1 of 12 (8%) mutants show a bifid C1

split cervical axis ( J:43344 )

• 5 of 12 (42%) mutants show a bifid C2

cervical vertebral transformation ( J:43344 )

• 1 of 12 (8%) mutants show anterior transformation of C2 to C1

fusion of vertebral arches ( J:43344 )

• 1 of 12 (8%) mutants show fusions of neural arches of C2 and C3

vision/eye

absent metoptic pillar ( J:43344 )

• 11 of 15 mutants exhibit agenesis of the metoptic pillar

narrow eye opening ( J:43344 )

• mutants display a mild reduction of the palpebral aperture at E14.5

craniofacial

abnormal basioccipital bone morphology ( J:43344 )

• 2 of 12 (17%) mutants exhibit a posterior tubercle on the basioccipital bone

absent metoptic pillar ( J:43344 )

• 11 of 15 mutants exhibit agenesis of the metoptic pillar

fusion of atlas and occipital bones ( J:43344 )

• 1 of 12 (8%) show fusion of the basioccipital bone with C1-AA

respiratory system

abnormal tracheal cartilage morphology ( J:43344 )

• 11 of 12 (92%) mutants show tracheal cartilage abnormalities