Phenotypes Associated with This Genotype

Genotype
MGI:3765991

• Allelic Composition: Tg(Ins2-Lta)#Flv/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

insulitis ( J:91820 )

• F1 offspring from crosses to C57BL/6 mice display mixed periinsulitis and insulitis

periinsulitis ( J:91820 )

• F1 offspring from crosses to C57BL/6 mice display mixed periinsulitis and insulitis

kidney inflammation ( J:91820 )

• focal infiltration of mononuclear cells is observed in all transgenic mice, while controls and Tnf-transgenic mice do not display this

renal/urinary system

kidney inflammation ( J:91820 )

• focal infiltration of mononuclear cells is observed in all transgenic mice, while controls and Tnf-transgenic mice do not display this

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:91820 )

• less islets (60-65%) display infiltrating mononuclear cells than Tnf-transgenic mice (100%) at 5 months of age

insulitis ( J:91820 )

• F1 offspring from crosses to C57BL/6 mice display mixed periinsulitis and insulitis

periinsulitis ( J:91820 )

• F1 offspring from crosses to C57BL/6 mice display mixed periinsulitis and insulitis