Phenotypes Associated with This Genotype

Genotype
MGI:3765990

• Allelic Composition: Tg(Ins2-Lta)#Flv/0
• Genetic Background: involves: NOD

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

insulitis ( J:91820 )

• F1 offspring from crosses to NOD mice display mixed periinsulitis and insulitis

periinsulitis ( J:91820 )

• F1 offspring from crosses to NOD mice display mixed periinsulitis and insulitis

kidney inflammation ( J:91820 )

• focal infiltration of mononuclear cells is observed in all F1 offspring from crosses to NOD mice mice, while controls and Tnf-transgenic mice do not display this

renal/urinary system

kidney inflammation ( J:91820 )

• focal infiltration of mononuclear cells is observed in all F1 offspring from crosses to NOD mice mice, while controls and Tnf-transgenic mice do not display this

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:91820 )

• less islets (60-65%) display infiltrating mononuclear cells than Tnf-transgenic mice from F1 crosses to NOD mice (seen in 100% of animals) at 5 months of age

• in prediabetic mice, CD4+ and CD8+ T cells represent 50% of infiltrating cells in islets; the other 50% are CD4/CD8 double negative cells

insulitis ( J:91820 )

• F1 offspring from crosses to NOD mice display mixed periinsulitis and insulitis

periinsulitis ( J:91820 )

• F1 offspring from crosses to NOD mice display mixed periinsulitis and insulitis