Phenotypes Associated with This Genotype

Genotype
MGI:3765969

• Allelic Composition: Tg(ACTB-NOTCH1)1Shn/?; Tg(Nes-cre/Esr1*)4Ynj/?
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:127227 )

N • no enlargement of lateral ventricles or defects in ependymal adhesion of ventricular walls are observed

increased neuron apoptosis ( J:127227 )

• overexpression of Notch1 in induced mutants results in significantly increased Doublecortin-positive neuroblast apoptosis at the striato-cortical junction

abnormal postnatal subventricular zone morphology ( J:127227 )

• overexpression of Notch1 in induced mutants results in significantly increased Doublecortin-positive neuroblast cellularity at the striato-cortical junction

cellular

increased neuron apoptosis ( J:127227 )

• overexpression of Notch1 in induced mutants results in significantly increased Doublecortin-positive neuroblast apoptosis at the striato-cortical junction