Phenotypes Associated with This Genotype

Genotype
MGI:3765900

• Allelic Composition: Cd1d1^tm1Luc/Cd1d1^tm1Luc
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

arrested T cell differentiation ( J:125679 )

• alpha-GalCer-CD1d-reactive T cells are a blocked in their development before reaching the DP^dull stage

decreased NK T cell number ( J:39748 )

• the percentages of natural T (NT) cells in the thymus, peripheral lymph nodes, and liver are reduced compared to in wild-type mice

• the percentage of CD4+ NK1.1 cells is reduced 10- to 20-fold while the number of CD4-CD8- NK1.1 cells is reduced 4- to 5-fold compared to in wild-type mice

• the percentage of NT cells in the peripheral lymphoid organs is reduced 3- to 5-fold while the percentage of CD4+CD8- NT cells is reduced 10-fold and the percentage CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice

• the percentage of CD4+CD8- NT cells is reduced 8-fold while the percentage of CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice

decreased interferon-gamma secretion ( J:93915 , J:39748 )

• in the liver after concanavalin A injection (J:93915)

• mice produce 2- to 9-fold less interferon-gamma than wild-type mice in response to anti-CD3 antibody stimulation (J:39748)

decreased interleukin-4 secretion ( J:39748 )

• splenocytes produce 9- to 25-fold less IL-4 than wild-type cells when stimulated with anti-CD3 antibodies

decreased tumor necrosis factor secretion ( J:93915 )

• in the liver after concanavalin A injection

decreased acute inflammation ( J:93915 )

• significantly reduced infiltration of neutrophiles into the liver after concanavalin A injection

hematopoietic system

arrested T cell differentiation ( J:125679 )

• alpha-GalCer-CD1d-reactive T cells are a blocked in their development before reaching the DP^dull stage

decreased NK T cell number ( J:39748 )

• the percentages of natural T (NT) cells in the thymus, peripheral lymph nodes, and liver are reduced compared to in wild-type mice

• the percentage of CD4+ NK1.1 cells is reduced 10- to 20-fold while the number of CD4-CD8- NK1.1 cells is reduced 4- to 5-fold compared to in wild-type mice

• the percentage of NT cells in the peripheral lymphoid organs is reduced 3- to 5-fold while the percentage of CD4+CD8- NT cells is reduced 10-fold and the percentage CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice

• the percentage of CD4+CD8- NT cells is reduced 8-fold while the percentage of CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice

liver/biliary system

abnormal liver morphology ( J:93915 )

• considerably less liver damage induced by concanavalin A injection than in controls

• as measured by alanine transaminase levels

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:93915 )

• considerably less liver damage induced by concanavalin A injection than in controls

• as measured by alanine transaminase levels